Division of Pharmacology, Andhra University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India
Abstract
Background: Testicular torsion and detorsion causes reperfusion injury which damages the testicular tissue and affects the quality of sperm. Deterioration in the quality of sperm worldwide is the recent scenario and one of its reasons is testicular ischemic/ reperfusion (IR) injury. Therefore the present study aims at producing new drugs for the treatment of testicular IR injury. Methods: 42 animals were selected for the study and divided into 7 groups, each containing 6 rats. Bioflavonoids were tested for their efficacy in reversing the damage done to the testicular tissue by causing testicular torsion and detorsion in rats. As oxidative stress produced in the above condition causes tissue damage, MDA level was measured and antioxidant enzymes SOD and catalse were evaluated. Histolo-gical examination was conducted to find the extent of damage and the protective effect of rutin and naringin. One-way ANOVA and Tukey’s post-hoc test were used for data analysis. A p-value
Akondi,B R , Challa,S R and Akula,A . (2011). Protective Effects of Rutin and Naringin in Testicular Ischemia-Reperfusion Induced Oxidative Stress in Rats. Journal of Reproduction & Infertility, 12(3), 209-214.
MLA
Akondi,B R , , Challa,S R , and Akula,A . "Protective Effects of Rutin and Naringin in Testicular Ischemia-Reperfusion Induced Oxidative Stress in Rats", Journal of Reproduction & Infertility, 12, 3, 2011, 209-214.
HARVARD
Akondi B R, Challa S R, Akula A. (2011). 'Protective Effects of Rutin and Naringin in Testicular Ischemia-Reperfusion Induced Oxidative Stress in Rats', Journal of Reproduction & Infertility, 12(3), pp. 209-214.
CHICAGO
B R Akondi, S R Challa and A Akula, "Protective Effects of Rutin and Naringin in Testicular Ischemia-Reperfusion Induced Oxidative Stress in Rats," Journal of Reproduction & Infertility, 12 3 (2011): 209-214,
VANCOUVER
Akondi B R, Challa S R, Akula A. Protective Effects of Rutin and Naringin in Testicular Ischemia-Reperfusion Induced Oxidative Stress in Rats. JRI. 2011;12(3):209-214.
