Journal of Reproduction & Infertility

Journal of Reproduction & Infertility

Comparing the Effects of Echinophora-platyloba, Fennel and Placebo on Pre-menstrual Syndrome

Authors
Masoumeh Delaram 1
Soleiman Kheiri 2
Mohammad Reza Hodjati 3
1 Department of Midwifery, Faculty of Nursing & Midwifery, Shahrekord University of Medical Science & Health Services, Shahr-e-Kord, Iran
2 Department of Statistic& Epidemiology, Faculty of Medicine, Shahrekord University of Medical Science, Shahr-e-Kord, Iran
3 Department of Physiology, Shahrekord University of Medical Sciences, Shahr-e-Kord, Iran
Abstract
Background: Premenstrual syndrome (PMS) is a condition characterized by a number of behavioral, psychological and physical symptoms recurring cyclically during the luteal phase of the menstrual cycle. The uncertainty in the pathogenesis of PMS has led to many treatment protocols being suggested as possible therapies. The present study was carried out to compare the effects of echinophora-platyloba and fennel extracts on the PMS against placebo in students of Shahrekord University of Medical Sciences in 2008. Methods: In this single-blind randomized clinical trial, 90 students with moderate to severe PMS enrolled in the study and were randomely divided into three equal groups. The first group received echinophora-platyloba extract, the second group received fennel extracts and the third group received placebo. The severity of PMS was measured by Daily Record of Severity of Problems (DRSP) questionnaire at the end of the first and second menstrual cycles before the intervention and the results were compared with them after the intervention. Data was analyzed using Dunn, Kruskal Wallis, and Pearson correlation tests by SPSS (v. 11.5) and P < 0.05 was considered statistically significant. Results: There were not any significant differences in the means of premenstrual syndrome scores before the intervention among the three groups (100.8±22.1 in echinophora-platyloba group, 101.3±27.1 in fennel group and 104.3±19.5 in placebo group, P > 0.05), but the differences were significant after the intervention (49.7±23.2 in echinophora-platyloba group, 64.4±27.5 in fennel group and 79.1±28.1 in placebo group, respectively, P < 0.001). No significant differences were seen between the echinophora-platyloba and fennel groups. Conclusion: The echinophora-platyloba and fennel extracts could reduce the severity of PMS. The effects of echinophora-platyloba and fennel were similar and greater than the placebo. Administration of the extracts of these herbs is suggested for relieving the signs and symptoms of PMS.
Keywords
Echinophora
platyloba
Fennel
Placebo
Premenstrual syndrome
Tschudin S, Bertea PC, Zemp E. Prevalence and predictors of premenstrual syndrome and premenstrual dysphoric disorder in a population-based sample. Arch Womens Ment Health. 2010;13(6): 485-94.
Nisar N, Zehra N, Haider G, Munir AA, Sohoo NA. Frequency, intensity and impact of premenstrual syndrome in medical students. J Coll Physicians Surg Pak. 2008;18(8):481-4.
Silva CM, Gigante DP, Carret ML, Fassa AG. [Population study of premenstrual syndrome]. Rev Saude Publica. 2006;40(1):47-56. Portuguese.
Wittchen HU, Becker E, Lieb R, Krause P. Prevalence, incidence and stability of premenstrual dysphoric disorder in the community. Psychol Med. 2002;32(1):119-32.
Potter J, Bouyer J, Trussell J, Moreau C. Premenstrual syndrome prevalence and fluctuation over time: results from a French population-based survey. J Womens Health (Larchmt). 2009;18(1):31-9.
Freeman MP. Screening and treatment for women with mood disorders associated with reproductive events. J Clin Psychiatry. 2007;68(12):1946.
Fujii H, Sakai R, Masatsugu A, Ohta M, Matsumoto T, Doi T, et al. Case of premenstrual syndrome inducing monthly episodes of vesiculobullous eruptions on the face. J Dermatol. 2008;35(4):246-7.
Pakgohar M, Ahmadi M, Salehi surmaghi MH, Mehran A, Akhondzadeh Sh. [Effect of Hypericum perforatum L. for treatment of premenstrual syndrome]. J Med Plants. 2005;4(3):33-42. Persian.
Bertone-Johnson ER. Vitamin D and the occurrence of depression: causal association or circumstantial evidence? Nutr Rev. 2009;67(8):481-92.
Landén M, Erlandsson H, Bengtsson F, Andersch B, Eriksson E. Short onset of action of a serotonin reuptake inhibitor when used to reduce premenstrual irritability. Neuropsychopharmacology. 2009;34(3):585-92.
Salehi L, Salehi F. [The effect of pyridoxine (vit B6) on premenstrual syndrome]. J kordestan Univ Med Sci. 2007;2(3):32-9. Persian.
Studd J, Panay N. Are oestrogens useful for the treatment of depression in women? Best Pract Res Clin Obstet Gynaecol. 2009;23(1):63-71.
peroff L, Fritz MA. Clinical gynecologic endocrinology and infertility. 7th ed. Philadelphia: Lippincott Williams & Wilkins; c2005. Chapter 14, Menstrual Disorders; p. 531-571 .
Jarvis CI, Lynch AM, Morin AK. Management strategies for premenstrual syndrome/premenstrual dysphoric disorder. Ann Pharmacother. 2008;42 (7):967-78.
Segebladh B, Borgström A, Nyberg S, Bixo M, Sundström-Poromaa I. Evaluation of different addback estradiol and progesterone treatments to gonadotropin-releasing hormone agonist treatment in patients with premenstrual dysphoric disorder. Am J Obstet Gynecol. 2009;201(2):139.e1-8.
Yazdani M, Shahriyary M, Hamedi B. [Comparison of fennel versus placebo on dysmenorrhea and PMS]. J Hormozgan Univ Med Sci. 2004;8(1):57-61. Persian.
Döll M. [The premenstrual syndrome: effectiveness of Vitex agnus castus]. Med Monatsschr Pharm. 2009;32(5):186-91.German.
Jing Z, Yang X, Ismail KM, Chen X, Wu T. Chinese herbal medicine for premenstrual syn-drome. Cochrane Database Syst Rev. 2009;(1): CD006414.
He Z, Chen R, Zhou Y, Geng L, Zhang Z, Chen S, et al. Treatment for premenstrual syndrome with Vitex agnus castus: A prospective, randomized, multi-center placebo controlled study in China. Maturitas. 2009;63(1):99-103.
Sadraei H, Asghari Gh, Yaghoubi Kh. [Study of the effect of hydro-Alcoholic and essential oil of Echinophora Platyloba on rat isolated ileum contractions in vitro]. J Res Med Sci. 2003;7(Suppl 2):150-5. Persian.
Avijgan M, Saadat M, Nilforooshzadeh MA, Hafi-zi M. [Anti fungal effect of Echinophora platyloba extract on some common dermathophytes]. J Med Plants. 2006;5(18):10-6. Persian.
Avijgan M, Mahboubi M, Darabi M, Kasaiyan N. [Anti candidal activity of Echinophora platyloba against candida albicans and comparison with Amphotricin]. J Med Plants. 2009;8(30):36-43. Persian.
Moura LS, Carvalho JR, Stefanini MB, Ming LC, Meireles MAA. Supercritical fluid extraction from fennel (Foeniculum vulgare): global yield, composition and kinetic data. J Supercrit Fluids. 2005; 35(3):212-9.
Birdane FM, Cemek M, Birdane YO, Gülçin I, Büyükokuroğlu ME. Beneficial effects of Foeniculum vulgare on ethanol-induced acute gastric mucosal injury in rats. World J Gastroenterol. 2007;13(4):607-11.
Shams Ardekani MR, Haji Akhoondi A, Jamshidi AH, Abdi Kh. [The study of volatile oil of Foeniculum Vulgare Miller in their tissue culture and comparison with the whole plant]. J Med Plants. 2005;4(15): 80-73. Persian.
Torkzahrani Sh, Akhavan-Amjadi M, Mojab F, Alavi Majd H. Clinical effects of Foeniculum vulgare extract on primary dysmenorrhea. J Reprod Infertil. 2007;8(1):45-51.
Modaress Nejad V, Motamedi B, Asadi pour M. [Comparison between the Pain-Relief Effect of Fennel and Mefenamic Acid on Primary Dysmenorrhea]. J Rafsanjan Univ Med Sci. 2006;5(1):1-6. Persian.
Ostad SN, Soodi M, Shariffzadeh M, Khorshidi N, Marzban H. The effect of fennel essential oil on uterine contraction as a model for dysmenorrhea, pharmacology and toxicology study. J Ethnopharmacol. 2001;76(3):299-304.
Borenstein JE, Dean BB, Yonkers KA, Endicott J. Using the daily record of severity of problems as a screening instrument for premenstrual syndrome. Obstet Gynecol. 2007;109(5):1068-75.
Entezari M, Hashemi M, Ashki M, Ebrahimian S, Bayat M, Azizi Saraji AR, et al. Studying the Effect Echinophora Platyloba Extract on Bactira (Staphilococus aureus and Pseudomonas aeroginosa) and Fungi (Candidia albicans, Aspergilus flavus and Aspergilus niger) In Vitro. World J Med Sci. 2009;4(2):89-92.
Shahhosseini Z, Amin Qh, Salehi sormaghi MH, Danesh MM. [Double blind study of anti primary dysmenorrhea effects of Vitagnus]. J Mazandaran Univ Med Sci. 2005;15(50):15-21. Persian.
Agajani Delavar M, Nasiri F, Hoseini SH. [A double-blind placebo-controlled evaluation of Vitex agnus castus in premenstrual syndrome]. J Med Plants.2002;1(2):15-21. Persian.
Ozgoli G, Selselei EA, Mojab F, Majd HA. A randomized, placebo-controlled trial of Ginkgo biloba L. in treatment of premenstrual syndrome. J Altern Complement Med. 2009;15(8):845-51.
Journal of Reproduction & Infertility
Volume 12, Issue 3
Summer 2011
Pages 221-226