Journal of Reproduction & Infertility

Journal of Reproduction & Infertility

Frequency of Antisperm Antibodies in Infertile Women

Authors
Batool Mutar Mahdi 1
Wafaa Hazim Salih 1
Annie Edmond Caitano 2
Bassma Maki Kadhum 1
Dina Sami Ibrahim 2
1 Al-Kindi College of Medicine, Baghdad University, Baghdad, Iraq
2 Central Public Health Laboratory, Baghdad, Iraq
Abstract
Background: Infertility is one of the common problems seen in couples of reproductive age. Presence of antisperm antibodies in semen and serum are amongst the causes of immunoinfertility. This study was performed to determine antisperm antibodies in cervicovaginal secretions and serum of infertile women and also measure serum levels of immunoglobulins (IgG, IgM and IgA). Methods: The study consisted of 45 infertile women consulting the Kammal ElSammrari Hospital for infertility from 2008 to 2009 and the control group consisted of 30 fertile women. Serum levels of immunoglobulins (IgG, IgA and IgM) were measured in the participants using single radial immune diffusion. Antisperm antibodies (ASAs) were detected in the serum of both infertile and control groups using indirect immune fluorescence test. ASAs were also detected in cervicovaginal secretion using direct sperm agglutination test in both infertile and control groups. Results: Antisperm antibodies were found in the cervicovaginal secretions (62.2%) and sera (64.4%) of infertile women which were significantly higher (p
Keywords
Antisperm antibody
Cervicovaginal
Immunoflourescence
Immunoglobulin
Infertility
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Journal of Reproduction & Infertility
Volume 12, Issue 4
Autumn 2011
Pages 261-265