Journal of Reproduction & Infertility

Journal of Reproduction & Infertility

Endometriosis: A History Written by Aberrant Hoxa10 Gene Expression and Epidermal Growth Factor (EGF) System Polymorphism?

Letter to Editor

Authors
Raffaella Mormile 1
Giorgio Vittori 2
1 Division of Pediatric and Neonatology, Moscati Hospital, Aversa, Italy
2 Division of Gynecology, San Carlo di Nancy Hospital, Rome, Italy
Abstract
Endometriosis is a gynecologic disorder characterized by the presence of viable, extrauterine endometrial tissue, predominantly on the ovary and pelvic peritoneum (1-3). Typical symptoms consist of pelvic pain, dysmenorrhea, and infertility (1, 2). This condition takes place only in women of menstrual age, can grow or bleed cyclically and may cause adhesions (1, 2). Endometriosis represents a worldwide social disease compromising quality of life (1, 2)....
  1. Giudice LC. Clinical practice. Endometriosis. N Engl J Med. 2010;362(25):2389-98.
  2. Ejskjaer K, Sorensen BS, Poulsen SS, Mogensen O, Forman A, Nexo E. Expression of the epidermal growth factor system in human endometrium during the menstrual cycle. Mol Hum Reprod. 2005;11(8): 543-51.
  3. Ejskjaer K, Sorensen BS, Poulsen SS, Mogensen O, Forman A, Nexo E. Expression of the epidermal growth factor system in eutopic endometrium from women with endometriosis differs from that in endometrium from healthy women. Gynecol Obstet Invest. 2009;67(2):118-26.
  4. Araújo AP, Catarino R, Ribeiro R, Pereira D, Pinto D, Medeiros R. Epidermal growth factor genetic variation associated with advanced cervical cancer in younger women. Am J Clin Oncol. 2012;35(3): 247-50.
  5. Aghajanova L, Giudice LC. Molecular evidence for differences in endometrium in severe versus mild endometriosis. Reprod Sci. 2011;18(3):229-51.
  6. Li-Kroeger D, Witt LM, Grimes HL, Cook TA, Gebelein B. Hox and senseless antagonism functions as a molecular switch to regulate EGF secretion in the Dro-sophila PNS. Dev Cell. 2008;15 (2):298-308.
  7. Zanatta A, Rocha AM, Carvalho FM, Pereira RM, Taylor HS, Motta EL, et al. The role of the Hoxa 10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review. J Assist Reprod Genet. 2010;27(12):701-10.
  8. Kim JJ, Taylor HS, Lu Z, Ladhani O, Hastings JM, Jackson KS, et al. Altered expression of HOXA10 in endometriosis: potential role in decidualization. Mol Hum Reprod. 2007;13(5):323-32.
Journal of Reproduction & Infertility
Volume 14, Issue 1
Winter 2013
Pages 46-47