Journal of Reproduction & Infertility

Journal of Reproduction & Infertility

Pharmacology of Free Radicals and the Impact of Reactive Oxygen Species on the Testis

Author
Jonah Aprioku
Department of Pharmacology, Faculty of Basic Medical Sciences, University of Port Harcourt, Port Harcourt, Nigeria
Abstract
The role of free radicals in normal cellular functions and different pathological conditions has been a focus of pharmacological studies in the recent past. Reactive oxygen species (ROS) and free radicals in general are essential for cell signaling and other vital physiological functions; however, excessive amounts can cause alteration in cellular reduction-oxidation (redox) balance, and disrupt normal biological functions. When there is an imbalance between activities of ROS and antioxidant/scavenging defense systems, oxidative stress (OS) occurs. A good number of studies have shown OS is involved in the development of several disease conditions, including male infertility. In the present article, generation of free radicals and their effects, as well as the mechanisms of antioxidant/scavenging defense systems are discussed, with particular focus on the testis. The review also discusses the contribution of OS on testicular dysfunction and briefly focuses on some OS-induced conditions that will alter testicular function.
Keywords
Antioxidant
ROS
scavenging
Superoxide anion
Testis
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Journal of Reproduction & Infertility
Volume 14, Issue 4
Autumn 2013
Pages 158-172