The Case of Sacrococcygeal Teratoma in an IVF Pregnancy: Is There any Association between Congenital Tumors and Assisted Reproduction Techniques?

Tempe, Anjali; Singh, Nilanchali; Sharma, Ila; Agarwal, Satish

The Case of Sacrococcygeal Teratoma in an IVF Pregnancy: Is There any Association between Congenital Tumors and Assisted Reproduction Techniques?

Authors

Anjali Tempe ¹

Nilanchali Singh ¹

Ila Sharma ¹

Satish Agarwal ²

¹ Department of Obstetrics and Gynaecology, Maulana Azad Medical College, New Delhi, India

² Department of Paediatric Surgery, Maulana Azad Medical College, New Delhi, India

Abstract

Background: Sacrococcygeal teratoma (SCT) is a rare congenital tumor and its association with IVF pregnancy is not clear. There are limited reports of congenital tumors in IVF pregnancy. The exact embryogenesis of SCT is not known but a genetic etiology has been reported. Whether these congenital tumors have any association with assisted reproductive techniques remains obscure. Case Presentation: In this study, a case of SCT in an IVF pregnancy with donor oocytes was reported. IVF was performed for bilateral tubal blockade and poor ovarian reserve. It was diagnosed antenatally by ultrasonography. Successful surgical treatment was performed in postnatal period and six months follow-up remained uneventful. Conclusion: The purpose of reporting this case is to emphasize on the possibility of association of congenital tumors with assisted reproductive techniques and hence, the need for screening in these pregnancies. An association could not be detected based on few case reports and therefore, large population based studies are required to elucidate the effect of these reproductive techniques on occurrence of congenital tumors.

Keywords

Assisted

Congenital tumors

IVF

Reproduction Techniques

Sacrococcygeal Teratoma

Chambers GM, Wang YA, Chapman MG, Hoang VP, Sullivan EA, Abdalla HI, et al. What can we learn from a decade of promoting safe embryo transfer practices? A comparative analysis of policies and outcomes in the UK and Australia, 2001-2010. Hum Reprod. 2013;28(6):1679-86.

Kallen B, Finnstrom O, Lindam A, Nilsson E, Nygren KG, Otterblad PO. Congenital malformations in infants born after in vitro fertilization in Sweden. Birth Defects Res A Clin Mol Teratol. 2010;88(3):137-43.

Bonduelle M, Liebaers I, Deketelaere V, Derde MP, Camus M, Devroey P, et al. Neonatal data on a cohort of 2889 infants born after ICSI (1991-1999) and of 2995 infants born after IVF (1983-1999). Hum Reprod. 2002;17(3):671-94.

Ericson A1, Kallen B. Congenital malformations in infants born after IVF: a population-based study. Hum Reprod. 2001;16(3):504-9.

Chisholm CA, Heider AL, Kuller JA, von Allmen D, McMahon MJ, Chescheir NC. Prenatal diagnosis and perinatal management of fetal sacrococcygeal teratoma. Am J Perinatol. 1999;16(1):47-50.

Avery GB, Fletcher MA, McDonald ME. Neonatology: pathophysiology and management of newborn. Philadelphia: Lippincott; 1994. p. 1219-20.

Wee WW, Tagore S, Tan JV, Yeo GS. Foetal sacrococcygeal teratoma: extremes in clinical presentation. Singapore Med J. 2011;52(6):e118-23.

Rescorla FJ, Sawin RS, Coran AG, Dillon PW, Azizkhan RG. Long-term outcome for infants and children with sacrococcygeal teratoma: a report from the Childrens Cancer Group. J Pediatr Surg. 1998;33(2):171-6.

Villa JC, John V, Verghella V. Large foetal sacrococcygeal teratoma complicated by preterm premature rupture of membranes and maternal preeclampsia. Rev Colomb Obstet Ginecol. 2007;58(4):322-27.

Chervenak FA, Isaacson G, Touloukian R, Tortora M, Berkowitz RL, Hobbins JC. Diagnosis and management of fetal teratomas. Obstet Gynecol. 1985 Nov;66(5):666-71.

Manzoni C, Canali R, Narciso A, Nanni L, Pintus C. [Sacrococcygeal teratoma: single center experience and functional long-term follow-up]. Clin Ter. 2011;162(2):99-106. Italian.

Anthony S, Buitendijk SE, Dorrepaal CA, Lindner K, Braat DD, den Ouden AL. Congenital malformations in 4224 children conceived after IVF. Hum Reprod. 2002;17(8):2089-95.

Rizk T, Nabbout R, Koussa S, Akatcherian C. Congenital brain tumor in a neonate conceived by in vitro fertilization. Childs Nerv Syst. 2000;16(8):501-2.

White L, Giri N, Vowels MR, Lancaster PA. Neuroectodermal tumours in children born after assisted conception. Lancet. 1990;336(8730):1577.

Morof DF, Levine D, Stringer KF, Grable I, Folkerth R. Congenital glioblastoma multiforme: prenatal diagnosis on the basis of sonography and magnetic resonance imaging. J Ultrasound Med. 2001;20(12):1369-75.

Olson CK, Keppler-Noreuil KM, Romitti PA, Budelier WT, Ryan G, Sparks AE, et al. In vitro fertilization is associated with an increase in major birth defects. Fertil Steril. 2005;84(5):1308-15.