Journal of Reproduction & Infertility

Journal of Reproduction & Infertility

Cervical Cancer Along with Unknown Cirrhosis: A Misdiagnosed Case

Authors
Soheila Aminimoghaddam 1
Fatemeh Mahmoudzadeh 2
Andisheh Maghsoudnia 3
1 Firoozgar Hospital, Iran University of Medical Sciencesy of Medical Sciences, Tehran, Iran
2 Mazandaran University of Medical Sciences, Sari, Iran
3 Tarbiat Modarres University, Tehran, Iran
Abstract
Background: Cervical cancer is the second most common malignancy in women worldwide. Vaginal bleeding and vaginal discharge are the most common symptoms. Although ascites has been reported in cases with cervical cancer, it is due to other causes such as ovarian metastasis. Case Presentation: A 78-year-old diabetic woman who presented with ascites and abdominopelvic mass was misdiagnosed with ovarian cancer and treated with neoadjuvant chemotherapy followed by radical hysterectomy and adjuvant radiotherapy. However, pathology confirmed locally advanced cervical cancer stage IV in this patient. She was discharged from the hospital three weeks after surgery with no serious complications. Discussion: Considering all signs and symptoms to reach a verdict would reduce such malpractices and consequently lead to select the best management and treatment.
Keywords
Diabetes Mellitus
Liver Cirrhosis
Misdiagnosed case
ovarian neoplasms
Uterine Cervical Neoplasms
  1. Solomon D, Breen N, McNeel T. Cervical cancer screening rates in the United States and the potential impact of implementation of screening guidelines. CA Cancer J Clin. 2007;57(2):105-11.
  2. International Collaboration of Epidemiological Studies of Cervical Cancer. Comparison of risk factors for invasive squamous cell carcinoma and adenocarcinoma of the cervix: collaborative reanalysis of individual data on 8,097 women with squamous cell carcinoma and 1,374 women with adenocarcinoma from 12 epidemiological studies. Int J Cancer. 2007;120(4):885-91.
  3. Zhan YS, Feng L, Tang SH, Li WG, Xu M, Liu TF, et al. Glucose metabolism disorders in cancer patients in a Chinese population. Med Oncol. 2010;27(2):177-84.
  4. Kuriki K, Hirose K, Tajima K. Diabetes and cancer risk for all and specific sites among Japanese men and women. Eur J Cancer Prev. 2007;16(1):83-9.
  5. Jee SH, Ohrr H, Sull JW, Yun JE, Ji M, Samet JM. Fasting serum glucose level and cancer risk in Korean men and women. JAMA. 2005;293(2):194-202.
  6. Subramaniam A, Fauci JM, Schneider KE, Whitworth JM, Erickson BK, Kim K, et al. Invasive cervical cancer and screening: what are the rates of unscreened and underscreened women in the modern era? J Low Genit Tract Dis. 2011;15(2):110-3.
  7. Nazari Z, Behtash N, Gilani MM, Ganjoei TA. Cervical carcinoma simulating advanced ovarian cancer. Eur J Surg Oncol. 2007;33(1):123-4.
  8. Abdulhathi MB, Al-Salam S, Kassis A, Ghazal-Aswad S. Unusual presentation of cervical cancer as advanced ovarian cancer. Arch Gynecol Obstet. 2007;276(4):387-90.
  9. Chemoradiotherapy for Cervical Cancer Meta-analysis Collaboration (CCCMAC). Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: individual patient data meta-analysis. Cochrane Database Syst Rev. 2010;(1):CD008285.
  10. Committee on Practice Bulletins-Gynecology. ACOG practice bulletin. Diagnosis and treatment of cervical carcinomas, number 35, May 2002. Obstet Gynecol. 2002;99(5 Pt 1):855-67.
  11. Yin M, Zhao F, Lou G, Zhang H, Sun M, Li C, et al. The long-term efficacy of neoadjuvant chemotherapy followed by radical hysterectomy compared with radical surgery alone or concurrent chemoradiotherapy on locally advanced-stage cervical cancer. Int J Gynecol Cancer. 2011;21(1):92-9.
  12. Rose PG. Locally advanced cervical cancer. Curr Opin Obstet Gynecol. 2001 Feb;13(1):65-70.
  13. Uddin MS, Hoque MI, Islam MB, Uddin MK, Haq I, Mondol G, et al. Serum-ascites albumin gradient in differential diagnosis of ascites. Mymensingh Med J. 2013;22(4):748-54.
  14. Tempe A, Singh S, Wadhwa L, Garg A. Conventional and color Doppler sonography in preoperative assessment of ovarian tumors. Int J Gynaecol Obstet. 2006;92(1):64-8.
  15. Skirnisdottir I, Garmo H, Holmberg L. Non-genital tract metastases to the ovaries presented as ovarian tumors in Sweden 1990-2003: occurrence, origin and survival compared to ovarian cancer. Gynecol Oncol. 2007;105(1):166-71.
  16. Hewitt MJ, Anderson K, Hall GD, Weston M, Hutson R, Wilkinson N, et al. Women with peritoneal carcinomatosis of unknown origin: Efficacy of image-guided biopsy to determine site-specific diagnosis. BJOG. 2007;114(1):46-50.
  17. Waggoner SE. Cervical cancer. Lancet. 2003;361(9376):2217-25.
  18. Bailey J, Cymet TC. Planning for the HPV vaccine and its impact on cervical cancer prevention. Compr Ther. 2006;32(2):102-5.
  19. Leary A, Pautier P, Tazi Y, Morice P, Duvillard P, Gouy S, et al. [The molecular biology of epithelial ovarian cancer]. Bull Cancer. 2012;99(12):1161-73. French.
  20. Geisler JP, Linnemeier GC, Thomas AJ, Manahan KJ. Nutritional assessment using prealbumin as an objective criterion to determine whom should not undergo primary radical cytoreductive surgery for ovarian cancer. Gynecol Oncol. 2007;106(1):128-31.
Journal of Reproduction & Infertility
Volume 16, Issue 3
Summer 2015
Pages 174-177