Journal of Reproduction & Infertility

Journal of Reproduction & Infertility

The Relationship Between Uterine Artery two-dimensional Color Doppler Measurement and Pregnancy Outcome: A Prospective Observational Study

Authors
Sudha Prasad 1
Ritu Goyal 1
Yogesh Kumar 1
Poonam Nayar 2
Supriya Hajela 1
Aswathy Kumaran 1
Rajesh Vairagi 1
Shalini Chauhan 1
1 Department of IVF and Reproductive Medicine, Maulana Azad Medical College & Associated Lok Nayak Hospitals, New Delhi, India
2 Mata Chanan Devi Hospital, New Delhi, India
Abstract
Background: The purpose of the study was to evaluate the role of uterine blood flow parameters measured by uterine artery two-dimensional (2D)-power color doppler (PCD) ultrasound in predicting fertility outcomes in women undergoing IVF-ET cycles. Methods: In this prospective observational study, a total of 188 infertile women who underwent IVF-ET cycles were investigated. Uterine artery 2D-PD measurements were taken during early follicular phase and on day of trigger. Pulsatility Index (PI), Resistant Index (RI), Peak Systolic Velocity (PSV), and Systolic/Diastolic ratio (S/D) were measured. Statistical correlation was sought between the doppler parameters and fertility outcomes. Results: The pregnancy rate was 40.43% (76/188). The women who conceived (n=76) (Group A) were found to have mean age of 31.2±3.9 years whereas the non-pregnant group of women (n=112) (Group B) had mean age of 31.45±4.25 years. The mean PI measurements subsequently during early follicular phase and on the day of hCG trigger between group A and group B were comparable (2.09±1.15 versus 1.9±0.95; p=0.385 and 1.86±1.12 versus 2.03±1.0; p=0.192, respectively). No significant changes in the uterine artery PSV values and S/D values and RI were noted during the cycle. Conclusion: Uterine artery doppler evaluation in women undergoing IVF cycles was not predictive of the pregnancy outcomes.
Keywords
Doppler ultrasound
Follicular phase
IVF
ET
Pregnancy Outcomes
Uterine Artery
National center for chronic disease prevention and health promotion. Assisted reproductive technology. Atlanta (GA): US Dept of Health and Human Services; 2014. 82 p.
Salle B, Bied-Damon V, Benchaib M, Desperes S, Gaucherand P, Rudigoz RC. Preliminary report of an ultrasonography and colour Doppler uterine score to predict uterine receptivity in an in-vitro fertilization programme. Hum Reprod. 1998;13(6):1669-73.
Steer CV, Tan SL, Dillon D, Mason BA, Campbell S. Vaginal color Doppler assessment of uterine artery impedance correlates with immunohistochemical markers of endometrial receptivity required for the implantation of an embryo. Fertil Steril. 1995;63(1):101-8.
Cacciatore B, Simberg N, Fusaro P, Tiitinen A. Transvaginal Doppler study of uterine artery blood flow in in vitro fertilization-embryo transfer cycles. Fertil Steril. 1996;66(1):130-4.
Goswamy RK, Steptoe PC. Doppler ultrasound studies of the uterine artery in spontaneous ovarian cycles. Hum Reprod. 1988;3(6):721-6.
Steer CV, Campbell S, Tan SL, Crayford T, Mills C, Mason BA, et al. The use of transvaginal color flow imaging after in vitro fertilization to identify optimum uterine conditions before embryo transfer. Fertil Steril. 1992;57(2):372-6.
Goswamy RK, Williams G, Steptoe PC. Decreased uterine perfusion--a cause of infertility. Hum Reprod. 1988;3(8):955-9.
Tekay A. Transvaginal Colour Doppler ultrasound in gynecology with special reference to Ovarian tumors, tubal pregnancy and assisted reproductive technologies [dissertation]. [Finland]: University of Oulu;1995. 100 p.
Tekay A, Martikainen H, Jouppila P. Blood flow changes in uterine and ovarian vasculature, and predictive value of transvaginal pulsed colour Doppler ultrasonography in an in-vitro fertilization programme. Hum Reprod. 1995;10(3):688-93.
Strohmer H, Herczeg C, Plöckinger B, Kemeter P, Feichtinger W. Prognostic appraisal of success and failure in an in vitro fertilization program by transvaginal Doppler ultrasound at the time of ovulation induction. Ultrasound Obstet Gynecol. 1991;1(4):272-4.
Favre R, Bettahar K, Grange G, Ohl J, Arbogast E, Moreau L, et al. Predictive value of transvaginal uterine Doppler assessment in an in vitro fertilization program. Ultrasound Obstet Gynecol. 1993;3(5):350-3.
Bassil S, Magritte JP, Roth J, Nisolle M, Donnez J, Gordts S. Uterine vascularity during stimulation and its correlation with implantation in in-vitro fertilization. Hum Reprod. 1995;10(6):1497-501.
Zaidi J, Pittrof R, Shaker A, Kyei-Mensah A, Campbell S, Tan SL. Assessment of uterine artery blood flow on the day of human chorionic gonadotropin administration by transvaginal color Doppler ultrasound in an in vitro fertilization program. Fertil Steril. 1996;65(2):377-81.
Tsai YC, Chang JC, Tai MJ, Kung FT, Yang LC, Chang SY. Relationship of uterine perfusion to outcome of intrauterine insemination. J Ultrasound Med. 1996;15(9):633-6.
Tekay A, Martikainen H, Jouppila P. The clinical value of transvaginal colour Doppler ultrasound in assisted reproductive technology procedures. Hum Reprod. 1996;11(8):1589-91.
Bustillo M, Krysa LW, Coulam CB. Uterine receptivity in an oocyte donation programme. Hum Reprod. 1995;10(2):442-5.
Deichert U, Albrand-Thielmann C, van de Sandt M. Doppler-sonographic pelvic blood flow measurements and their prognostic value in terms of luteal phase and implantation. Hum Reprod. 1996;11(8):1591-3.
World Health Organization. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 4th ed. UK: Cambridge University Press; 1999. 118 p.
Journal of Reproduction & Infertility
Volume 18, Issue 2
Spring 2017
Pages 251-256