Journal of Reproduction & Infertility

Journal of Reproduction & Infertility

The Effects of Adjuvant Therapies on Embryo Transfer Success

Authors
Rachael Shirlow 1
Martin Healey 2
Michelle Volovsky 3
Vivien Maclachlan 4
Beverley Vollenhoven 5
1 Monash University, Melbourne, Australia; Monash Health, Melbourne, Australia
2 University of Melbourne, Melbourne, Australia; Royal Women’s Hospital, Melbourne, Australia; Monash IVF, Melbourne, Australia
3 Monash University, Melbourne, Australia; Royal Melbourne Hospital, Melbourne, Australia
4 Monash IVF, Melbourne, Australia
5 Monash University, Melbourne, Australia; Monash Health, Melbourne, Australia; Monash IVF, Melbourne, Australia
Abstract
Background: Many adjuvant therapies are employed during IVF treatment in an attempt to improve outcomes. The objective of our study was to evaluate the impact of thirteen adjuvants (Intralipid, steroids, melatonin, coenzyme Q10, Filgrastim, testosterone, DHEA, growth hormone, antibiotics, hCG infusion, aspirin, enoxaparin/heparin and dopamine agonists) on the success of embryo transfers. Methods: This is a retrospective cohort study of all embryo transfers between January 2010 and April 2015 from a multi-site IVF clinic. To ensure data independence, random number was applied to each included transfer and used to pick an individual transfer for each patient (n=13,372). Outcomes were clinical pregnancy, live birth and pregnancy loss. Univariate comparison with Chi square testing and logistic regression analysis were used. The level of significance was p<0.05. Results: Steroid use was significantly associated with both reduced clinical pregnancy loss (aOR 0.39, CI 0.19-0.76) and improved live birth rates (aOR 1.40, CI 1.11-1.77). While aspirin was associated with improved live birth rates (aOR 1.48, CI 1.08-2.02), melatonin was linked with reduced rates (aOR 0.66, CI 0.45-0.96). Analyses for all other adjuvant therapies did not reach statistical significance after logistic regression. Conclusion: Many of the interventions investigated in this study fail to significantly demonstrate any effects on the success of embryo transfers. Our analysis results show negative effects with the use of melatonin; however, use of aspirin or steroids demonstrated promising, potentially beneficial outcomes. Additional exploration is needed to guide evidence-based practice.
Keywords
Adjuvant drug therapy
aspirin
Melatonin
Steroids
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Journal of Reproduction & Infertility
Volume 18, Issue 4
Autumn 2017
Pages 368-378