Journal of Reproduction & Infertility

Journal of Reproduction & Infertility

Effect of Aromatherapy with Peppermint Oil on the Severity of Nausea and Vomiting in Pregnancy: A Single-blind, Randomized, Placebo-controlled trial

Authors
Narges Joulaeerad 1
Giti Ozgoli 2
Homa Hajimehdipoor 3
Erfan Ghasemi 4
Fatemeh Salehimoghaddam 1
1 Student Research Committee, Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Midwifery and Reproductive Health Research Center, Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Department of Biostatistics, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract
Background: Nausea and vomiting are common complaints in the first half of pregnancy. These symptoms can significantly affect a person's personal and professional life. Aromatherapy is one of the types of complementary medicine that is used in the treatment of nausea and vomiting. The objective of this study was to determine the effect of aromatherapy with peppermint oil on the severity of nausea and vomiting of pregnancy (NVP). Methods: This was a single-blind clinical trial that was conducted on 56 pregnant women with mild to moderate severity of NVP and 6 to 20 weeks of gestational age. After the determination of gestational age and base severity of NVP in each woman, they were randomly assigned to one of the two groups: peppermint oil (n=28) or placebo (n=28). Inhalation aromatherapy was done for four days and at the end of each day,they responded to the Pregnancy Unique Quantification of Emesis/Nausea questionnaire (PUQE). The data obtained were analyzed with Mann-Whitney test and ANOVA with repeated measures using SPSS software version 22. Also, the level of significance was p<0.05. Results: Although the severity of NVP in each intervention group significantly decreased (p<0.001), the comparison of the severity of NVP during the study period and at the end of it was not statistically significant between the placebo and intervention groups. Conclusion: According to the possibility of neurological mechanisms causing NVP, the effect of aromatherapy with peppermint oil and placebo were the same in this study. This similarity can be due to psychological impacts of intervention on pregnant women.
Keywords
Mentha piperita
aromatherapy
Inhalation
Nausea
Pregnancy
Vomiting
Refuerzo JS, Smith JA, Ramin SM. Clinical features and evaluation of nausea and vomiting of pregnancy [Internet]. Waltham, MA: UpToDate Inc; 2015 April 25 [cited 2017 Jun 3]. Available from: https://www.uptodate.com/contents/clinical-features-and-evaluation-of-nausea-and-vomiting-of-pregnancy
Einarson T, Piwko C, Koren G. Quantifying the global rates of nausea and vomiting of pregnancy: a meta analysis. J Popul Ther Clin Pharmacol. 2012;20(2):171-83.
Herrell HE. Nausea and vomiting of pregnancy. Am Fam Physician. 2014;89(12):965-70.
Badell ML, Ramin SM, Smith JA. Treatment options for nausea and vomiting during pregnancy. Pharmacotherapy. 2006;26:1273-87.
Munch S, Korst LM, Hernandez GD, Romero R, Goodwin TM. Health-related quality of life in women with nausea and vomiting of pregnancy: the importance of psychosocial context. J Perinatol. 2011;31(1):10-20.
Lee NM, Saha S. Nausea and vomiting of pregnancy. Gastroenterol Clin North Am. 2011;40(2):309-34.
Niebyl JR. Clinical practice. Nausea and vomiting in pregnancy. N Eng J Med. 2010;363(16):1544-50.
Firouzbakht M, Nikpour M, Omidvar Sh, Kiapour A. Comparative Study of Effects of ginger with vit. B6 in treatment nausea and vomiting during pregnancy. J Fam Health. 1391;1(3):8-13.
Hollyer T, Boon H, Georgousis A, Smith M, Einarson A, et al. The use of CAM by women suffering from nausea and vomiting during pregnancy. BMC complement Altern Med. 2002;2:5.
Abedzadeh Kalahroudi M. Complementary and alternative medicine in midwifery. Nurs Midwifery Stud. 2014;3(2):e19449.
Ghani RMA, Ibrahim ATA. The effect of aromatherapy inhalation on nausea and vomiting in early pregnancy: a pilot randomized controlled trial. J Nat Sci Res. 2013;3(6):192-205.
Fundukian LJ. The gale encyclopedia of alternative medicine. 4th ed. United States of America: Thomson Gale; 2014. 2848 p.
Thomson F. PDR for herbal medicines. 4th ed. Montvale, New Jersey: Thomson; 2007. 1026 p.
World Health Organization. WHO monographs on medicinal plants commonly used in the newly independent states (NIS). 1st ed. Geneva: WHO Press; 2010. Aetheroleum menthae piperitae; p. 251-70.
Lawless J. The encyclopedia of essential oils: the complete guide to the use of aromatic oils in aromatherapy, herbalism, health and well being. 1st ed. San Francisco: Red Wheel Weiser; 2013. 224 p.
Mills SY, Bone K, Mills S, Bone K. The essential guide to herbal safety. 1st ed. United States of America: Elsevier Churchill Livingstone; 2005. 704 p.
Verma RS, Rahman L, Verma RK, Chauhan A, Yadav AK, Singh A. Essential oil composition of menthol mint (Mentha arvensis) and peppermint (Mentha piperita) cultivars at different stages of plant growth from Kumaon region of western Himalaya. Open Access J Med Aromat Plants. 2010;1(1):13-8.
Tisserand R, Young R. Essential oil safety: a guide for health care professionals. 2nd ed. Edinburg: Churchill Livingstone Elsevier; 2014. 780 p.
Heimes K, Hauk F, Verspohl EJ. Mode of action of peppermint oil and (-)-menthol with respect to 5‐HT3 receptor subtypes: binding studies, cation uptake by receptor channels and contraction of isolated rat ileum. Phytother Res. 2011;25(5):702-8.
US Food and Drug Administration [Internet]. Washington: US Department of Health and Human Services; C2014. Food additive status list. [cited 2014 Dec 23]; [about 60 screens]. Available from: http://www.fda.gov/food/ingredientspackaginglabeling/foodadditivesingredients/ucm091048.htm#ftnP
Hashem Dabaghian F. Knowledge of pregnant women about the efficacy and safety of herbal medicine and their practice during pregnancy. J Complement Med. 2012;2(3):246-56.
Koren G, Piwko C, Ahn E, Boskovic R, Maltepe C, Einarson A, et al. Validation studies of the pregnancy unique-quantification of emesis (PUQE) scores. J Obstet Gynecol. 2005;25(3):241-4.
Ebrahimi, N, Maltepe C, Bournissen FG, Koren G. Nausea and vomiting of pregnancy: using the 24-hour pregnancy-unique quantification of emesis (PUQE-24) scale. J Obstet Gynaecol. 2009;31(9):803-7.
National Association for Holistic Aromatherapy [Internet]. North Carolina: NAHA; C2014. Methods of application. [cited 2014 Apr 15]; [about 7 screens]. Available from: https://www.naha.org/explore-aromatherapy/about-aromatherapy/methods-of-application/
Pasha H, Behmanesh F, Mohsenzadeh F, Hajahmadi M, Moghadamnia AA. Study of the effect of mint oil on nausea and vomiting during pregnancy. Iran Red Crescent Med J. 2012;14(11):727-30.
Anderson LA, Gross JB. Aromatherapy with peppermint, isopropyl alcohol, or placebo is equally effective in relieving postoperative nausea. J Perianesth Nurs. 2004;19(1):29-35.
Sites DS, Johnson NT, Miller JA, Torbush PH, Hardin JS, Knowles SS, et al. Controlled breathing with or without peppermint aromatherapy for postoperative nausea and/or vomiting symptom relief: a randomized controlled trial. J Perianesth Nurs. 2014;29(1):12-9.
Journal of Reproduction & Infertility
Volume 19, Issue 1
Winter 2018
Pages 32-38