Journal of Reproduction & Infertility

Journal of Reproduction & Infertility

Angiotensin Type 2 Receptor Gene Polymorphisms and Susceptibility to Preeclampsia

Authors
Mohammad Sadegh Soltani-Zangbar 1
Behnoush Pahlavani 2
Jaleh Zolghadri 3
Behrouz Gharesi-Fard 4
1 Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2 Islamic Azad University, Fars Science and Research Branch, Shiraz, Iran
3 Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4 Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract
Background: The purpose of the study was to determine the relationship between angiotensin II type 1 receptor at position+1166 (AT1R+1166A/C; rs5186) and angiotensin II type 2 receptor at position+1675 (AT2R+1675A/G; rs5194) gene polymorphisms with preeclampsia in an Iranian women population. Methods: 430 women were recruited in this study including 212 preeclamptics and 218 healthy women. PCR-RFLP method was used for genotyping the polymorphisms. Chi square and Fisher exact test were used for comparing case and control groups. The p<0.05 was considered statistically significant. Results: The frequency of genotypes of the AT1R gene and AT2R gene was similar in preeclampsia and normal pregnancy. There were no significant differences in genotype and also allele frequencies between preeclamptics and healthy women regarding the two studied polymorphisms. AT1R/AT2R genotypes combination study indicated that there was a statistically significant difference between preeclamptics and healthy women. AC/AG combination was significantly decreased, while CC/AA combination showed significant increase in patients compared with the healthy women (p<0.01). Conclusion: The present study showed that the genetic polymorphisms within AT1R and AT2R genes may be associated with susceptibility to preeclampsia in Iranian women.
Keywords
AT1R
AT2R
Polymorphism
preeclampsia
Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet. 2005;365(9461):785-99.
Li H, Ma Y, Fu Q, Wang L. Angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensin II type 1 receptor (AT1R) gene polymorphism and its association with preeclampsia in Chinese women. Hypertens Pregnancy. 2007;26(3):293-301.
Rochat RW, Koonin LM, Atrash HK, Jewett JF. Maternal mortality in the United States: report from the maternal mortality collaborative. Obstet Gynecol. 1988;72(1):91-7.
Wallis AB, Saftlas AF, Hsia J, Atrash HK. Secular trends in the rates of preeclampsia, eclampsia, and gestational hypertension, United States, 1987-2004. Am J Hypertens. 2008;21(5):521-6.
Leeman L, Fontaine P. Hypertensive disorders of pregnancy. Am Fam physician. 2008;78(1):93-100.
Salimi S, Mokhtari M, Yaghmaei M, Jamshidi M, Naghavi A. Association of angiotensin-converting enzyme intron 16 insertion/deletion and angiotensin II type 1 receptor A1166C gene polymorphisms with preeclampsia in south east of Iran. J Biomed Biotechnol. 2011;2011:941515.
Demir C, Evruke C, Ozgunen FT, Urunsak IF, Candan E, Kadayifci O. Factors that influence morbidity and mortality in severe preeclampsia, eclampsia and hemolysis, elevated liver enzymes, and low platelet count syndrome. Saudi Med J. 2006;27(7):1015-8.
Akbar SA, Khawaja NP, Brown PR, Tayyeb R, Bamfo J, Nicolaides KH. Angiotensin II type 1 and 2 receptors gene polymorphisms in Preeclampsia and normal pregnancy in three different populations. Acta Obstet Gynecol Scand. 2009;88(5):606-11.
Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, et al. Molecular basis of human hypertension: role of angiotensinogen. Cell. 1992;71(1):169-80.
Plummer S, Tower C, Alonso P, Morgan L, Baker P, Broughton‐Pipkin F, et al. Haplotypes of the angiotensin II receptor genes AGTR1 and AGTR2 in women with normotensive pregnancy and women with preeclampsia. Hum Mutat. 2004;24(1):14-20.
Bonnardeaux A, Davies E, Jeunemaitre X, Fery I, Charru A, Clauser E, et al. Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension. 1994;24(1):63-9.
Berry C, Touyz R, Dominiczak A, Webb RC, Johns D. Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide. Am J Physiol Heart Circ Physiol. 2001;281(6):H2337-65.
Sethupathy P, Borel C, Gagnebin M, Grant GR, Deutsch S, Elton TS, et al. Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3′ untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes. Am J Hum Genet. 2007;81(2):405-13.
Erdmann J, Guse M, Kallisch H, Fleck E, Regitz-Zagrosek V. Novel intronic polymorphism (+ 1675G/A) in the human angiotensin II subtype 2 receptor gene. Hum Mutat. 2000;15(5):487.
Jin JJ, Nakura J, Wu Z, Yamamoto M, Abe M, Chen Y, et al. Association of angiotensin II type 2 receptor gene variant with hypertension. Hypertens Res. 2003;26(7):547-52.
Behravan J, Naghibi M, Mazloomi MA, Hassany M. Polymorphism of angiotensin II type 1 receptor gene in essential hypertension in Iranian population. Daru. 2006;14(2):82-6.
Zhang L, Yang H, Qin H, Zhang K. Angiotensin II type I receptor A1166C polymorphism increases the risk of pregnancy hypertensive disorders: Evidence from a meta-analysis. J Renin Angiotensin Aldosterone Syst. 2014;15(2):131-8.
Perez-Sepulveda A, Torres MJ, Khoury M, Illanes SE. Innate immune system and preeclampsia. Front Immunol. 2014;5:244.
Smith CJ, Saftlas AF, Spracklen CN, Triche EW, Bjonnes A, Keating B, et al. Genetic risk score for essential hypertension and risk of preeclampsia. Am J Hypertens. 2016;29(1):17-24.
Staff AC, Johnsen GM, Dechend R, Redman CW. Preeclampsia and uteroplacental acute atherosis: immune and inflammatory factors. J Reprod Immunol. 2014;101-102:120-6.
Baudin B. Polymorphism in angiotensin II receptor genes and hypertension. Exp Physiol. 2005;90(3):277-82.
Alkanli N, Sipahi T, Kilic TO, Sener S. Lack of association between ACE I/D and AGTR1 A1166C gene polymorphisms and preeclampsia in Turkish pregnant women of Trakya region. J Gynecol Obstet. 2014;2(4):49-53.
Bouba I, Makrydimas G, Kalaitzidis R, Lolis DE, Siamopoulos KC, Georgiou I. Interaction between the polymorphisms of the renin–angiotensin system in preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2003;110(1):8-11.
Kobashi G, Hata A, Ohta K, Yamada H, Kato EH, Minakami H, et al. A1166C variant of angiotensin II type 1 receptor gene is associated with severe hypertension in pregnancy independently of T235 variant of angiotensinogen gene. J Hum Genet. 2004;49(4):182-6.
Nałogowska-Głośnicka K, Łacka B, Zychma MJ, Grzeszczak W, Zukowska-Szczechowska E, Poreba R, et al. Angiotensin II type 1 receptor gene A1166C polymorphism is associated with the increased risk of pregnancy-induced hypertension. Med Sci Monit. 2000;6(3):523-9.
Zhou A, Dekker GA, Lumbers ER, Lee SY, Thompson SD, McCowan L, et al. The association of AGTR2 polymorphisms with preeclampsia and uterine artery bilateral notching is modulated by maternal BMI. Placenta. 2013;34(1):75-81.
Journal of Reproduction & Infertility
Volume 19, Issue 2
Spring 2018
Pages 95-99