Comparing the Impact of Autologous Platelet-rich Plasma and Granulocyte Colony Stimulating Factor on Pregnancy Outcome in Patients with Repeated Implantation Failure

Mehrafza, Marzieh; Kabodmehri, Roya; Nikpouri, Zahra; Pourseify, Gholamreza; Raoufi, Azadeh; Eftekhari, Azadeh; Samadnia, Sajedeh; Hosseini, Ahmad

Comparing the Impact of Autologous Platelet-rich Plasma and Granulocyte Colony Stimulating Factor on Pregnancy Outcome in Patients with Repeated Implantation Failure

Authors

Marzieh Mehrafza ¹

Roya Kabodmehri ²

Zahra Nikpouri ¹

Gholamreza Pourseify ¹

Azadeh Raoufi ¹

Azadeh Eftekhari ¹

Sajedeh Samadnia ¹

Ahmad Hosseini ¹

¹ Mehr Fertility Research Center, Guilan University of Medical Science, Rasht, Iran

² Reproductive Health Research Center, Department of Obstetrics and Gynecology, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran

Abstract

Background: Despite the advancements in assisted reproductive technologies, repeated implantation failure (RIF) still remains a challenging problem for patients and clinicians. The aim of the present study was to compare the impact of intrauterine infusion of autologous platelet-rich plasma (PRP) and systemic administration of granulocyte colony stimulating factor (GCSF) on pregnancy outcome in patients with repeated implantation failure. Methods: The present retrospective cohort study included 123 patients with history of more than two repeated failed embryo transfers. Cycles were divided into two groups of intrauterine infusion of PRP (n=67) and systemic administration of GCSF (n=56). Pregnancy outcome was compared between two groups. The p-value less than 0.05 was considered statistically significant. Results: The clinical pregnancy rate was significantly higher in PRP group than GCSF group (40.3% versus 21.4%, p=0.025). The crud and adjusted odds ratios (95% confidence interval (CI)) were 2.5 and 2.6 (p=0.025, CI: 1.11-5.53 and p=0.03, CI: 1.10-6.15), respectively. Conclusion: It seems that intrauterine infusion of PRP can positively affect pregnancy outcome in RIF patients in comparison with systemic administration of GCSF and more studies need to be designed to conclude the effectiveness of this method.

Keywords

Granulocyte colony

stimulating factor

platelet

Rich Plasma

Repeated implantation failure

Volume 20, Issue 1
Winter 2019
Pages 35-41

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Journal of Reproduction & Infertility

Comparing the Impact of Autologous Platelet-rich Plasma and Granulocyte Colony Stimulating Factor on Pregnancy Outcome in Patients with Repeated Implantation Failure

Volume 20, Issue 1Winter 2019Pages 35-41

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Volume 20, Issue 1
Winter 2019
Pages 35-41