Journal of Reproduction & Infertility

Journal of Reproduction & Infertility

Metabolomics of Male Infertility: A New Tool for Diagnostic Tests

Authors
Bahareh Mehrparavar 1
Arash Minai-Tehrani 2
Babak Arjmand 3
Kambiz Gilany 4
1 Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
2 Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
3 Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Integrative Oncology Department, Breast Cancer Resear
4 Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran; Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
Abstract
Infertility is a major health issue worldwide. Males and females contribute equally to this problem. Diagnostic semen analysis fails to identify 50% of male infertility disorders. In this regard, metabolomics as a new field of omics has been suggested to have the potential of solving and diagnosis of the male infertility problems. Metabolome has a history of around 20 years. However, there are only limited metabolomics studies carried out regarding male infertility. In this review, the current metabolomics researches that have been done in infertile men were reviewed. Based on our own results, using human seminal plasma for metabolomics studies is highly recommended to find potential biomarkers and developing diagnosis tests for detection of main deficiencies in infertile men.
Keywords
Biomarkers
Human seminal plasma
Male infertility
metabolomics
Journal of Reproduction & Infertility
Volume 20, Issue 2
Spring 2019
Pages 64-69