Journal of Reproduction & Infertility

Journal of Reproduction & Infertility

Enhancing a Successful Pregnancy and Delivery After ICSI in Advanced-Age Woman with Concurrent Disorders: A Case Report

Authors
1 Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Department of Social Sciences, Razi University, Kermanshah, Iran
3 Infertility Research and Treatment Center, Motazedi Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
Abstract
Background: The objective of this case presentation was describing a live birth in an advanced-age woman with an extremely enlarged uterus, an ovary with blocked fallopian tubes, hypothyroidism and generalized anxiety disorder caused by childbirth following intracytoplasmic sperm injection/embryo transfer (ICSI-ET) with autologous oocytes. Case Presentation: A 47-year-old patient with an enlarged uterus due to recurrent multiple fibroids following myomectomy was referred to clinical laboratory with a high level of desire to follow the prescribed recommendations and approaches to retrieve her fertility. The patient underwent two cycles of oocyte retrieval and two rounds of frozen-thawed embryo transfer. To achieve a successful pregnancy after oocyte retrieval (birth weight of 3300 g at 38 weeks of gestation), a frozen/thawed embryo in the second cycle of ET was transferred. Conclusion: Usage of efficient planning and management of ICSI treatments in patient with autologous oocytes and concurrent disorders, can be used as a new approach to cure the affected individuals.
Keywords

  1. Kenny LC, Lavender T, McNamee R, O’Neill SM, Mills T, Khashan AS. Advanced maternal age and adverse pregnancy outcome: evidence from a large contemporary cohort. PloS one. 2013;8(2):e56583.
  2. Su YY, Wang SH, Chou HC, Chen CY, Hsieh WS, Tsao PN, et al. Morbidity and mortality of very low birth weight infants in Taiwan-Changes in 15 years: a population based study. J Formos Med Assoc. 2016;115(12):1039-45.
  3. Elizur SE, Lerner-Geva L, Levron J, Shulman A, Bider D, Dor J. Factors predicting IVF treatment outcome: a multivariate analysis of 5310 cycles. Reprod Biomed Online. 2005;10(5):645-9.
  4. Vander B, Mélodie, Christine W. Fertility and infertility: definition and epidemiology. Clin Biochem. 2018;60(4):2-10.
  5. Deatsman S, Vasilopoulos T, Rhoton-Vlasak A. Age and fertility: a study on patient awareness. JBRA Assist Reprod. 2016;20(3):99-106.
  6. Ajayi R, Parsons JH, Bolton VN. Live births after intracytoplasmic sperm injection in the management of oligospermia and azoospermia in Nigeria. Afr J Reprod Health. 2003;7(1):121-4.
  7. Rani G, Goswami S, Chattopadhyay R, Ghosh S, Chakravarty B, Ganesh A. Live birth in a 50-year-old woman following in vitro fertilization–embryo transfer with autologous oocytes: a rare case report. Fertil Steril. 2015;103(2):414-6.
  8. Orazulike N, Oriji VK, Fiebai PO. Live birth after in-vitro fertilization (IVF) in a 53 year old woman: a case report. Nigerian Health J. 2013;13(3):142-5.
  9. Ciavattini A, Di Giuseppe J, Stortoni P, Montik N, Giannubilo SR, Litta P, et al. Uterine fibroids: pathogenesis and interactions with endometrium and endomyometrial junction. Obstet Gynecol Int. 2013;2013:173184.
  10. Drayer SM, Catherino WH. Prevalence, morbidity, and current medical management of uterine leiomyomas. Int J Gynecol Obstet. 2015;131(2):117-22.
  11. Ikhena DE, Bulun SE. Literature review on the role of uterine fibroids in endometrial function. Reprod Sci. 2018;25(5):635-43.
  12. Verma I, Sood R, Juneja S, Kaur S. Prevalence of hypothyroidism in infertile women and evaluation of response of treatment for hypothyroidism on infertility. Int J Appl Basic Med Res. 2012;2(1):17-9.
  13. Krassas GE. Thyroid disease and female reproduction. Fertil Steril. 2000;74(6):1063-70.
  14. Pushpagiri N, Gracelyn LJ, Nagalingam S. Prevalence of subclinical and overt hypothyroidism in infertile women. Int J Reprod Contraception Obstet Gynecol. 2017;4(6):1733-8.
  15. Collict M, Baron YM, Gatt M, Calleja N. Maternal risks associated with pregnancy in women with advanced maternal age. Malta Med J. 2018;30(2):5-13.
  16. Klipstein S, Regan M, Ryley DA, Goldman MB, Alper MM, Reindollar RH. One last chance for pregnancy: a review of 2,705 in vitro fertilization cycles initiated in women age 40 years and above. Fertil Steril. 2005;84(2):435-45.
  17. Dal Prato L, Borini A, Cattoli M, Preti MS, Serrao L, Flamigni C. Live birth after IVF in a 46-year-old woman. Reprod Biomed Online. 2005;11(4):452-4.
  18. Jansen RP. The effect of female age on the likelihood of a live birth from one in-vitro fertilisation treatment. Med J Aust. 2003;178(6):258-61.
  19. Somigliana E, Vercellini P, Daguati R, Pasin R, De Giorgi O, Crosignani PG. Fibroids and female reproduction: a critical analysis of the evidence. Hum Reprod Update. 2007;13(5):465-76.
  20. Gianaroli L, Gordts S, D'Angelo A, Magli MC, Brosens I, Cetera C, et al. Effect of inner myometrium fibroid on reproductive outcome after IVF. Reprod Biomed Online. 2005;10(4):473-7.
  21. Volgsten H, Skoog Svanberg A, Ekselius L, Lundkvist Ö, Sundström Poromaa I. Prevalence of psychiatric disorders in infertile women and men undergoing in vitro fertilization treatment. Hum Reprod. 2008;23(9):2056-63.