Dietary Fatty Acid Intakes and the Outcomes of Assisted Reproductive Technique in Infertile Women

Jahangirifar, Maryam; Taebi, Mahboubeh; Nasr-Esfahani, Mohammad Hossein; Heidari-Beni, Motahar; Asgari, Gholam Hossein

doi:10.18502/jri.v22i3.6718

Dietary Fatty Acid Intakes and the Outcomes of Assisted Reproductive Technique in Infertile Women

Authors

Maryam Jahangirifar ¹

Mahboubeh Taebi ²

Mohammad Hossein Nasr-Esfahani ³

Motahar Heidari-Beni ⁴

Gholam Hossein Asgari ⁵

¹ School of Nursing and Midwifery, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia

² Department of Midwifery and Reproductive Health, Isfahan University of Medical Sciences, Isfahan, Iran

³ Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran

⁴ Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

⁵ Department of Community Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran

10.18502/jri.v22i3.6718

Abstract

Background: The purpose of this study was evaluating the relationship between fatty acid (FA) intakes and the Assisted Reproductive Technique (ART) outcomes in infertile women. Methods: In this descriptive longitudinal study, a validated food frequency questionnaire (FFQ) was used to measure dietary intakes among 217 women with primary infertility seeking ART treatments at Isfahan Fertility and Infertility Center, Isfahan, Iran. The average number of total and metaphase II (MII) oocytes, the fertilization rate, the ratio of good and bad quality embryo and biochemical and clinical pregnancy were assessed. Analyses were performed using mean, standard deviation, Chi-square test, ANOVA, ANCOVA, logistic regression. Results: A total of 140 women were finally included in the study. There was a positive relationship between the average number of total and MII oocytes and the amount of total fatty acids (TFAs), saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), polyunsaturated fatty acids (PUFAs), linoleic acids, linolenic acids, and oleic acids intakes, while eicosapentaenoic acids (EPAs) and docosahexaenoic acids (DHAs) intakes had an inverse relationship. Consuming more amounts of TFAs, SFAs, PUFAs, MUFAs, linoleic acids, and oleic acids was associated with the lower fertilization rate, whereas the consumption of linolenic acids and EPAs increased the fertilization rate. The ratio of good quality embryo was directly affected by the amount of PUFAs intakes. Additionally, there was a negative correlation between the amount of SFAs intakes and the number of pregnant women. Conclusion: TFAs, SFA, PUFA, and MUFA intakes could have both beneficial and adverse impacts on ART outcomes.

Keywords

Assisted reproductive technique

Dietary Fats

In vitro fertilization

Infertility

Nutrition assessment

Rizk B, Olsen ME. Challenging Office Cases in Obstetrics and Gynecology. Johnson City: Jaypee Brothers Medical Publishers Ltd; 2016. p. 65-65.

Ramesh B, Kurkuri SN. Role of combined hystero-laparoscopy in the evaluation of female infertility as one step procedure. Int J Reprod Contraception Obstet Gynecol. 2016;5:396-401.

Dirkavand Moghaddam A, Delpisheh A, Sayehmiri K. The prevalence of infertility in Iran, a systematic review. Iran J Obstet Gynecol Infertil. 2013;16(8):1-7.

Centers for Disease Control and Prevention, American Society for Reproductive Medicine, Society for Assisted Reproductive Technology. 2014 Assisted reproductive technology: National summary report. Atlanta (GA): US Dept of Health and Human Services; 2016. Report No.: GS-23F-8144H.

Kelly T, Yang W, Chen CS, Reynols K, He J. Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond). 2008;32(9):1431-7.

Mmbaga N, Luk J. The impact of preconceptual diet on the outcome of reproductive treatments. Curr Opin Obstet Gynecol. 2012;24(3):127-31.

Leroy JL, Vanholder T, Delanghe JR, Opsomer G, Van Soom A, Bols PE, et al. Metabolic changes in follicular fluid of the dominant follicle in high-yielding dairy cows early post partum. Theriogenology. 2004;62(6):1131-43.

Gu L, Liu H, Gu X, Boots C, Moley KH, Wang Q. Metabolic control of oocyte development: linking maternal nutrition and reproductive outcomes. Cell Mol Life Sci. 2015;72(2):251-71.

Pohlmeier WE, Xie F, Kurz SG, Lu N, Wood JR. Progressive obesity alters the steroidogenic response to ovulatory stimulation and increases the abundance of mRNAs stored in the ovulated oocyte. Mol Reprod Dev. 2014;81(8):735-47.

Mirabi P, Chaichi MJ, Esmaeilzadeh S, Jorsaraei SG, Bijani A, Ehsani M, et al. The role of fatty acids on ICSI outcomes: a prospective cohort study. Lipids Health Dis. 2017;16(1):18.

Haggarty P, Wood M, Ferguson E, Hoad G, Srikantharajah A, Milne E, et al. Fatty acid metabolism in human preimplantation embryos. Hum Reprod. 2006;21(3):766-73.

Marei WF, Wathes DC, Fouladi-Nashta AA. Impact of linoleic acid on bovine oocyte maturation and embryo development. Reproduction. 2010;139(6):979-88.

McKeegan PJ, Sturmey RG. The role of fatty acids in oocyte and early embryo development. Reprod Fertil Dev. 2011;24(1):59-67.

Renaville B, Bacciu N, Comin A, Motta M, Poli I, Vanini G, et al. Plasma and follicular fluid fatty acid profiles in dairy cows. Reprod Domest Anim. 2010;45(1):118-21.

Fayezi S, Leroy JL, Novin MG, Darabi M. Oleic acid in the modulation of oocyte and preimplantation embryo development. Zygote. 2018;26(1):1-13.

Aardema H, Vos PL, Lolicato F, Roelen BA, Knijn HM, Vaandrager AB, et al. Oleic acid prevents detrimental effects of saturated fatty acids on bovine oocyte developmental competence. Biol Reprod. 2011;85(1):62-9.

Jorritsma R, Cesar ML, Hermans JT, Kruitwagen CL, Vos PL, Kruip TA. Effects of non-esterified fatty acids on bovine granulosa cells and developmental potential of oocytes in vitro. Anim Reprod Sci. 2004;81(3-4):225-35.

Mennitti LV, Oliveira JL, Morais CA, Estadella D, Oyama LM, do Nascimento CM, et al. Type of fatty acids in maternal diets during pregnancy and/or lactation and metabolic consequences of the offspring. J Nutr Biochem. 2015;26(2):99-111.

Dumesic DA, Meldrum DR, Katz-Jaffe MG, Krisher RL, Schoolcraft WB. Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health. Fertil Steril. 2015;103(2):303-16.

Mirmiran P, Esfahani FH, Mehrabi Y, Hedayati M, Azizi F. Reliability and relative validity of an FFQ for nutrients in the Tehran lipid and glucose study. Public Health Nutr. 2010;13(5):654-62.

Hosseini Esfahani F, Asghari G, Mirmiran P, Azizi F. Reproducibility and relative validity of food group intake in a food frequency questionnaire developed for the Tehran Lipid and Glucose Study. J Epidemiol. 2010;20(2):150-8.

Esmaillzadeh A, Mirmiran PA, Azizi F. Whole-grain consumption and the metabolic syndrome: a favorable association in Tehranian adults. Eur J Clin Nutr. 2005;59(3):353-62.

Craig CL, Marshall AL, Sjöström M, Bauman AE, Booth ML, Ainsworth BE, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003;35(8):1381-95.

Moghaddam MB, Aghdam FB, Jafarabadi MA, Allahverdipour H, Nikookheslat SD, Safarpour S. The Iranian version of international physical activity questionnaire (IPAQ) in Iran: content and construct validity, factor structure, internal consistency and stability. World Appl Sci J. 2012;18(8):1073-80.

Azadi-Yazdi M, Karimi-Zarchi M, Salehi-Abargouei A, Fallahzadeh H, Nadjarzadeh A. Effects of dietary approach to stop hypertension diet on androgens, antioxidant status and body composition in overweight and obese women with polycystic ovary syndrome: a randomised controlled trial. J Hum Nutr Diet. 2017;30(3):275-83.

Langbeen A, Bartholomeus E, Leroy JL, Bols PE. Bovine in vitro reproduction models can contribute to the development of (female) fertility preservation strategies. Theriogenology. 2015;84(4):477-89.

27. Valckx SD, Leroy JL. The effect of maternal metabolic health and diet on the follicular fluid composition and potential consequences for oocyte and embryo quality. In: Watson R, editor. Handbook of Fertility. USA: Academic Press; 2015. p. 35-44.

Salehi R, Colazo MG, Oba M, Ambrose DJ. A prepartum diet supplemented with oilseeds high in oleic or linoleic acid reduced GnRH-induced LH release in dairy cows during second week postpartum. Reprod Biol Endocrinol. 2015;13:69.

Bilby TR, Block J, Do Amaral BC, Sa Filho O, Silvestre FT, Hansen PJ, et al. Effects of dietary unsaturated fatty acids on oocyte quality and follicular development in lactating dairy cows in summer. J Dairy Sci. 2006;89(10):3891-903.

Roura M, Catalá MG, Soto-Heras S, Hammami S, Izquierdo D, Fouladi-Nashta A, et al. Linoleic (LA) and linolenic (ALA) acid concentrations in follicular fluid of prepubertal goats and their effect on oocyte in vitro maturation and embryo development. Reprod Fertil Dev. 2018;30(2):286-96.

Pratt HP, George MA. Organisation and assembly of the surface membrane during early cleavage of the mouse embryo. Roux's Arch Dev Biol. 1989;198(3):170-8.

Veshkini A, Khadem AA, Mohammadi-Sangcheshmeh A, Alamouti AA, Soleimani M, Gastal EL. Linolenic acid improves oocyte developmental competence and decreases apoptosis of in vitro-produced blastocysts in goat. Zygote. 2016;24(4):537-48.

Lee JE, Yong H, Kim HY, Lee WH, Cheong HT, Yang BK, et al. Effect of alpha-linolenic acid on oocyte maturation and embryo development in pigs. Dev Reprod. 2017;21(2):205-13.

Marei WF, Wathes DC, Fouladi-Nashta AA. The effect of linolenic acid on bovine oocyte maturation and development. Biol Reprod. 2009;81(6):1064-72.

Calder MD, Caveney AN, Westhusin ME, Watson AJ. Cyclooxygenase-2 and prostaglandin E2 (PGE2) receptor messenger RNAs are affected by bovine oocyte maturation time and cumulus-oocyte complex quality, and PGE2 induces moderate expansion of the bovine cumulus in vitro. Biol Reprod. 2001;65(1):135-40.

Abayasekara DR, Wathes DC. Effects of altering dietary fatty acid composition on prostaglandin synthesis and fertility. Prostaglandins Leukot Essent Fatty Acids. 1999;61(5):275-87.

Murakami K, Chan SY, Routtenberg A. Protein kinase C activation by cis-fatty acid in the absence of Ca2+ and phospholipids. J Biol Chem. 1986;261(33):15424-9.

Frey MR, Clark JA, Leontieva O, Uronis JM, Black AR, Black JD. Protein kinase C signaling mediates a program of cell cycle withdrawal in the intestinal epithelium. J Cell Biol. 2000;151(4):763-78.

Ciepiela P, Bączkowski T, Drozd A, Kazienko A, Stachowska E, Kurzawa R. Arachidonic and linoleic acid derivatives impact oocyte ICSI fertilization–a prospective analysis of follicular fluid and a matched oocyte in a ‘one follicle–one retrieved oocyte–one resulting embryo’ investigational setting. PLoS One. 2015;10(3):e0119087.

Chen S, Yao L, Cunningham TJ. Secreted phospholipase A2 involvement in neurodegeneration: differential testing of prosurvival and anti-inflammatory effects of enzyme inhibition. PloS One. 2012;7(6):e39257.

Igosheva N, Abramov AY, Poston L, Eckert JJ, Fleming TP, Duchen MR, et al. Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes. PloS One. 2010;5(4):e10074.

Wu LL, Russell DL, Norman RJ, Robker RL. Endoplasmic reticulum (ER) stress in cumulus-oocyte complexes impairs pentraxin-3 secretion, mitochondrial membrane potential (ΔΨm), and embryo development. Mol Endocrinol. 2012;26(4):562-73.

Wu LL, Dunning KR, Yang X, Russell DL, Lane M, Norman RJ, et al. High-fat diet causes lipotoxicity responses in cumulus–oocyte complexes and decreased fertilization rates. Endocrinology. 2010;151(11):5438-45.

Leroy JL, Vanholder T, Mateusen B, Christophe A, Opsomer G, de Kruif A, et al. Non-esterified fatty acids in follicular fluid of dairy cows and their effect on developmental capacity of bovine oocytes in vitro. Reproduction. 2005;130(4):485-95.

Tripathi SK, Nandi S, Gupta PS, Mondal S. Influence of common saturated and unsaturated fatty acids on development of ovine oocytes in vitro. Asian J Anim Sci. 2015;9:420-6.

Alves JPM, Bertolini M, Bertolini LR, Silva CMG, Rondina D. Lipotoxicity: impact on oocyte quality and reproductive efficiency in mammals. Anim Reprod Belo Horiz. 2015;12(2):291-7.

Hammiche F, Vujkovic M, Wijburg W, de Vries JH, Macklon NS, Laven JS, et al. Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology. Fertil Steril. 2011;95(5):1820-3.

Broughton KS, Rule DC, Ye Y, Zhang X, Driscoll M, Culver B. Dietary omega-3 fatty acids differentially influence ova release and ovarian cyclooxygenase-1 and cyclooxygenase-2 expression in rats. Nutr Res. 2009;29(3):197-205.

Mattos R, Staples CR, Williams J, Amorocho A, McGuire MA, Thatcher WW. Uterine, ovarian, and production responses of lactating dairy cows to increasing dietary concentrations of menhaden fish meal. J Dairy Sci. 2002;85(4):755-64.

Amaya-Montoya C, Matsui M, Kawashima C, Hayashi KG, Matsuda G, Kaneko E, et al. Induction of ovulation with GnRH and PGF(2 alpha) at two different stages during the early postpartum period in dairy cows: ovarian response and changes in hormone concentrations. J Reprod Dev. 2007;53(4):867-75.

Wathes DC, Cheng Z, Mareiy W, Fouladi-Nashta A. Polyunsaturated fatty acids and fertility in female mammals: An update. CAB Rev Perspect Agric Vet Sci Nutr Nat Resour. 2013;8(041):1-14.

Shahnazi V, Zaree M, Nouri M, Mehrzad-Sadaghiani M, Fayezi S, Darabi M, et al. Influence of ω-3 fatty acid eicosapentaenoic acid on IGF-1 and COX-2 gene expression in granulosa cells of PCOS women. Iran J Reprod Med. 2015;13(2):71-8.

Toori MA, Mosavi E, Nikseresht M, Barmak MJ, Mahmoudi R. Influence of insulin-like growth factor-i on maturation and fertilization rate of immature oocyte and embryo development in NMRI mouse with TCM199 and α-MEM medium. J Clin Diagn Res. 2014;8(12):AC05-8.

Cerri RL, Juchem SO, Chebel RC, Rutigliano HM, Bruno RG, Galvao KN, et al. Effect of fat source differing in fatty acid profile on metabolic parameters, fertilization, and embryo quality in high-producing dairy cows. J Dairy Sci. 2009;92(4):1520-31.

Thangavelu G, Colazo MG, Ambrose DJ, Oba M, Okine EK, Dyck MK. Diets enriched in unsaturated fatty acids enhance early embryonic development in lactating Holstein cows. Theriogenology. 2007;68(7):949-57.

Gueyffier F, Cucherat M. The limitations of observation studies for decision making regarding drugs efficacy and safety. Therapie. 2019;74(2):181-5.