Journal of Reproduction & Infertility

Journal of Reproduction & Infertility

Comparison of Obstetric Outcomes Between IVF cycles with Donor Oocyte and Spontaneous Conception Pregnancies: A Retrospective Cohort study

Authors
Yadav Vikas 1
Malhotra Neena 2
Mahey Reeta 2
Singh Neeta 2
Kriplani Alka 2
1 Department of Obstetrics and Gynecology, School of Medical Sciences and Research, Sharda Hospital, Sharda University Campus, Uttar Pradesh, India
2 Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India
10.18502/jri.v23i2.8994
Abstract
Background: Oocyte donation has facilitated couples to achieve pregnancy in conditions like diminished ovarian reserve, premature ovarian failure, and inheritable disorders. However, it is unclear whether pregnancy complications are due to oocyte donation per se or due to confounding factors such as maternal age or the allogenic fetus. In this retrospective comparative cohort, an attempt was made to evaluate and compare multiple obstetric and perinatal outcomes. Methods: The present study comprised all women in the age range of 20-45 years who conceived from oocyte donation (n=102) between 1/12/2011 to 30/09/2017. Control group consisted of spontaneous conception cases (n=306) in ratio of 1:3 with no previous medical or surgery comorbidity. Obstetric and perinatal outcomes were compared between two groups. Results: Mean maternal age was significantly higher in the donor oocyte IVF group (group 1; 35.13 years) as compared to spontaneous conception group (group 2; 31.75 years). Parity between the two groups was comparable. Pregnancy induced hypertension (PIH) was seen in 33.33% of cases in group 1 as compared to 7.18% in group 2. Moreover, gestational diabetes mellitus was seen in 34.31% of cases in group 1 as compared to 9.47% in group 2 (p=0.001). By the same token, there was significant difference in perinatal outcomes between the two groups. Conclusion: Oocyte donation should be treated as an independent risk factor for miscarriage, hypertensive disorder, and gestational diabetes mellitus in pregnancy.
Keywords
Bleeding in first trimester
Gestational diabetes mellitus
Oocyte Donation
pregnancy induced hypertension
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Journal of Reproduction & Infertility
Volume 23, Issue 2
Spring 2022
Pages 100-106