Evaluation of L-Carnitine Potential in Improvement of Male Fertility

Kooshesh, Leila; Nateghian, Zohre; Aliabadi, Elham

doi:10.18502/jri.v24i2.12491

Evaluation of L-Carnitine Potential in Improvement of Male Fertility

Authors

Leila Kooshesh ¹

Zohre Nateghian ²

Elham Aliabadi ³

¹ Department of Genetics, Fars Academic Center for Education, Culture and Research, ACECR, Shiraz, Iran

² Islamic Azad University of Isfahan (Khorasgan) Branch, Isfahan, Iran

³ Department of Anatomy, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

10.18502/jri.v24i2.12491

Abstract

L-carnitine, through its antioxidant potential, plays a significant role in reducing ROS production in male genital tract; therefore, fundamental improvements in spermatogenesis process and sperm structural and functional parameters in seminal plasma can be observed by treatment with L-carnitine. A literature search was performed using PubMed (including Medline) from the database earliest inception to 2021. Eligibility criteria included studies on protective effects of L-carnitine against damages to the male reproductive system. Based on the findings of the current study, L-carnitine has an effective potential to protect testis and improve conventional and functional sperm parameters against ROS-induced damages by sperm cryopreservation, busulfan treatment, and radiation.

Keywords

busulfan

Carnitine

Male Fertility

Radiation

Sperm cryopreservation

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