Journal of Reproduction & Infertility

Journal of Reproduction & Infertility

The Effect of Progesterone Elevation on the Day of Trigger Administration: A Review of the Literature

Authors
Chris Jreij 1
Rawad Halimeh 2
Doha Fadel 1
Perla Chamoun 1
Jean Nassar 3
Wael Saab 2
Srividya Seshadri 2
Marianne Bersaoui 3
1 Faculty of Medicine, University of Balamand, Beirut, Lebanon
2 Clinical Department, The Centre for Reproductive and Genetic Health, London, United Kingdom
3 Faculty of Medicine, University of Balamand, Beirut, Lebanon; Department of Obstetrics and Gynecology, Saint George Hospital University Medical Center, Beirut, Lebanon
10.18502/jri.v25i2.16005
Abstract
Since the advent of assisted reproductive technology, different variables have been shown to affect pregnancy outcomes. One of the most prevalent studied events is the premature rise in serum progesterone concentrations on the day of trigger administration during cycles of ovarian stimulation. This phenomenon, classically known as premature luteinization, has been observed significantly for decades and has been linked to adverse pregnancy outcomes and lower live birth rates. Ultimately, a quest to find a precise serum progesterone concentration cut-off value that can be effectively used to predict pregnancy outcomes prior to trigger administration is still underway. The purpose of the current research was to study the available literature on the relationship between serum progesterone on the day of trigger administration in controlled ovarian stimulation cycles used for IVF in an attempt to identify a cut-off serum progesterone concentration that can be used to effectively predict future pregnancy outcomes in fresh transfers. This study is a review of the literature and is based on information and data gathered from 36 published jri_articles. The majority of the literature shows that a serum progesterone concentration cut-off of 1.5 ng/ml (4.77 nmol/L) can be used prior to trigger administration to effectively predict pregnancy outcomes. Premature progesterone elevation on the day or prior to the trigger administration is associated with adverse pregnancy outcomes in IVF cycles. Other factors such as follicle number, serum concentration of other hormones, and ovarian response to ovarian stimulation should also be considered to predict the success of IVF protocols.
Keywords
Embryo implantation
Embryo transfer
Endometrium
In vitro fertilization
Oocyte collection
Ovarian hyperstimulation syndrome
Ovarian stimulation
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Journal of Reproduction & Infertility
Volume 25, Issue 2
Spring 2024
Pages 102-109