Journal of Reproduction & Infertility

Journal of Reproduction & Infertility

The effect of estrogenic mycotoxins in fertility disorder

Authors
Mahmoud Ghazi Khansari 1
Mohammad Rasoul Hadiani 2
1 Department of Pharmacology, Faculty of Medicine, Tehran Medical Sciences University, Tehran, Iran
2 Food and Drug Control Labs (FDCL), Ministry of Health & Medical Education, Tehran, Iran
Abstract
Mycotoxins are naturally secondary metabolites of filamentous fungi, more specifically molds, that have adverse effects on biological organisms. A class of mycotoxins with estrogenic activity is Estrogenic mycotoxins (mycoestrogens) that produced by Fusarium fungi. The only class of mycoestrogens so far determined is the zearalenones (ZEAs). Zearalenones are non-steroidal compounds belonged to -resorcylic acid lactones. ZEAs can bind estrogen receptors because they are able to adopt a conformation sufficiently resembling 17 -estradiol and other natural estrogens. For this reason, ZEAs have shown to cause alterations in the reproductive tract of laboratory and domestic animals, resulting in estrogenic syndrome. ZEAs have been observed to possess tumor-promoting activity in the human similar to that of estrogens and hypothetically can induce proliferation and carcinogenesis in estrogen dependent tissues such as endometrium and cervix. ZEAs were suspected to be the causative agent in some epidemics of precocious pubertal changes such as premature thelarche and gynecomastia in young children in some countries. Contamination of cereals especially corn with fusarium fungi, produces ZEAs. Therefore, routine laboratory determination of mycotoxins especially zearalenones are necessary to evaluate contamination rate of fungi toxins.
Keywords
Corn
Estrogenic
Infertility
Mycotoxins
Zearalenone
Pittet A. Natural occurrences of mycotoxins in foods and feeds: an updated review. Rev Med Vet. 1998;149:479-92.
Opinion of the Scientific Committee of European Commission on Food: fusarium toxins: Zearalenone (ZEA). 2000.
Shier W.T. Estrogenic mycotoxins. Rev Med Vet. 1998;149:599-604.
Shier W.T., Shier A.C., Xie W., et al. Structure activity relationships for human estrogenic activity in zearalenone mycotoxins. 2001;39:1435-8.
Hussein H. S., Brasel J. M. Toxicity, metabolism and impact of mycotoxins on human and animals. Toxicol. 2001;167:101-34.
Kuiper-Goodman T., Scott P.M., Watanabe H.Risk assessment of the mycotoxin zearalenone. Regulatory Toxicol Pharmacol. 1987;7:253-306.
Eriksen G.S., Alexander J. Fusarium toxins in cereals: a risk assessment. Nordic Council of Ministers.Tema Nord. 1998;502:7-27,45-58.
Kuiper G.G., Lemmen J.G., Carlsson B., et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endrocrinol. 1998;139:4252-63.
JECFA: Joint FAO/WHO Expert Committee on Food Additives. 53th Report. Safety evaluation of certain food additives. WHO Food Additives series 44. 2002.
Edwards S., Cantley T.C., Rottinghaus G.E., et al. The effects of zearalenone on reproduction in swine I. The relationship between ingested zearalenone dose and anoestrus in non-pregnant, sexually mature gilts. Theriogenol. 1987;28:43-9.
Tomaszewski J., Miturski R., Semczuk A., et al. Tissue zearalenone concentration in normal, hyperplastic and neoplastic human endometrium. Ginekol Pol. 1998;69:363-6.
Freni-Titulaer L.W., Cordero J.F., Haddock L., et al. Premature thelarche in puerto Rico a search Premature thelarche in Puerto Rico: a search for environmental factors. Am J Dis Child. 1986;140:1263-7.
Szuetz P., Mesterhazy A., Falkey G.Y. Early thelarche symptoms in children and their relations to zearalenone contamination in foodstuffs. Cereals Res Com. 1997;25:429-36.
Hadiani M. R., Ghazi-Khansari M., Cheraghali A. M. Determination of mycotoxin zearalenone
هادیانی محمد رسول. تعیین مقدار مایکوتوکسین زیرالنون در ذرت با روش TLC-Densitometry. پایان نامه کارشناسی ارشد سم‌شناسی پزشکی، دانشکده پزشکی دانشگاه علوم پزشکی و خدمات بهداشتی، درمانی تهران، 81-1380.
Boutrif E., Canet C. Mycotoxin prevention and control: FAO programs. Rev Med Vet. 1998;149 (6):681-94.
Arukwe A., Grotmol T., Haugen T.B., et al. Fish model for assessing the in vivo estrogenic potency of the mycotoxin zearalenone and its metabolites. Sci Total Environ.1999;236:153-61.
Journal of Reproduction & Infertility
Volume 4, Issue 1
Winter 2003
Pages 75-82