Journal of Reproduction & Infertility

Journal of Reproduction & Infertility

Evaluating course of pregnancy in women with infertility due to PCOS and on Metformin

Authors
Farnaz Sohrabvand 1
Malek Mansour Aghsa 1
Fedyeh Haghollahi 2
Maryam Bagheri 2
Mamak Shariat 2
Ashraf Alyasin 1
Farid Zayeri 3
1 Department of Gynecology and Obstetrics ,Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2 Vali-e- Asar Reproductive Health Research Center,Tehran Medical Sciences University, Tehran, Iran
3 Biostatistics Department, Faculty of Medicine, Shahed University of Medical Sciences, Tehran, Iran
Abstract
Introduction: Polycystic Ovary Syndrome (PCOS), which affects 2-20% of women of repro-ductive age, is associated with insulin resistance, hyperandrogenic anovulation and consequently infertility. In addition, in case of getting pregnant, there is a higher risk of spontaneous abortion. This study was done to evaluate the effects of continuing metformin throughout the first trimester of pregnancy. Materials & Methods: Seventy six PCOS patients who became pregnant while on ovulation induction medications and metformin were allocated to three groups in three different clinics during 2004-2005, as it follows: Group A, continuing metformin until the end of the 8th week, group B, until the end of the 12th week and group C, cessation of taking metformin immediately after confirmation of pregnancy (5-6th week of pregnancy). Pregnancy outcomes and complica-tions were followed until the end of pregnancies. The data were analyzed by using SPSS (Version 9) and χ2, t-test, ANOVA, Kruskal Wallis, McNemars test and logistic regression calculations. A p-value
Keywords
Fetal anomalies
Gestational diabetes
Infertility
Metformin
Polycystic ovary syndrome
Pregnancy
Spontaneous abortion
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Journal of Reproduction & Infertility
Volume 8, Issue 1
Spring 2007
Pages 23-29